Substitute Dirk Kuyt struck two minutes from time to give hosts Liverpool a 2-1 FA Cup fourth-round victory over Manchester United on Saturday with visiting captain Patrice Evra being booed throughout and making a mistake for the winner.
Sheffield United pulled off the first major shock of FA Cup third round weekend when the third-tier English side triumphed 3-0 at Premier League outfit Queens Park Rangers on Sunday.
Premier League Newcastle United's FA Cup hopes floundered on England's south coast for the second year in a row as Championship club Brighton and Hove Albion kicked off third round action with a 2-0 victory on Saturday.
The Premier League's two best teams and two most prolific strikers go head to head in the FA Cup on Saturday when Manchester United take on Arsenal in a huge fifth-round tie at Old Trafford (1715 GMT).
Benni McCarthy's stunning goal three minutes from time sent Blackburn Rovers into the quarter-finals of the FA Cup after a 1-0 win over Arsenal in a mostly lifeless fifth-round replay on Wednesday.
Liverpool striker Andy Carroll headed an 87th minute winner to secure a 2-1 victory over Merseyside rivals Everton in an error-strewn FA Cup semi-final at Wembley Stadium on Saturday.
Wigan Athletic's shock 1-0 win over Manchester City in the FA Cup final on Saturday not only caused one of the biggest upsets in the competition's history but could dictate the immediate futures of both managers.
Promoted Sunderland, who have defied expectations to stay in the top half of the Premier League table, could be the worst affected with six players going to the tournament, while the likes of Fulham, Manchester United, Burnley and Crystal Palace will also have to make do without some key personnel.
Chelsea manager Frank Lampard was delighted with the discipline of his team, who ended United's 19-game unbeaten run.
Liverpool's Charlie Adam will miss the FA Cup final against Chelsea on May 5 after having his season cut short by a knee injury, manager Kenny Dalglish said on Thursday.
Fernando Torres scored his first goal since October to help Chelsea crush Leicester City 5-2 and Liverpool beat Stoke City 2-1 to reach the FA Cup semi-finals on Sunday.
Arsenal's bid to win the FA Cup for a third successive year ended on Sunday when they lost 2-1 at home to Watford in a pulsating quarter-final tie.
Third tier Peterborough United produced the performance of the FA Cup fourth round when they twice came from behind in the dying minutes to earn a 2-2 draw at Premier League West Bromwich Albion on Saturday.
Manchester City survived some jitters to beat Championship (second division) Leicester City 4-2 in a lively FA Cup third round replay at Eastlands on Tuesday.
Crystal Palace set up a repeat of the 1990 FA Cup final against Manchester United after Yannick Bolasie and Connor Wickham securd a 2-1 victory over Watford at Wembley on Sunday.
Arsenal joined Manchester United and Liverpool on the FA Cup scrapheap on Sunday when Ricardo Fuller's double helped Stoke City to a 3-1 fourth round victory at the Britannia Stadium.
FA Cup holders Chelsea booked their place in the fifth round with a comfortable 2-0 victory over Championship (second division) side Preston North End on Saturday.
Bookies have placed Premier League leaders Chelsea as the new clear favourites with 3-1 odds to retain the FA Cup following Sunday's fourth-round draw.
Bert Trautmann, a former German Prisoner of War who became a footballer in England and famously broke his neck playing in goal for Manchester City in the 1956 FA Cup final, died on Friday at the age of 89.
It might not save manager Antonio Conte's job but Chelsea can still salvage a disappointing season by winning Saturday's FA Cup final
The Merseysiders fell behind to a Raul Jimenez goal on the break in the 38th minute, the Mexican firing home confidently after Diogo Jota robbed James Milner.
Two goals for Roman Pavlyuchenko and two own goals helped Tottenham Hotspur advance to an FA Cup quarter-final meeting with Fulham after a 4-0 home win over Bolton Wanderers in their fifth-round replay on Wednesday.
Arsenal recovered from going two goals down in the opening eight minutes to beat Hull City 3-2 after extra time in the FA Cup final and win their first trophy for nine years at Wembley on Saturday.
Arsenal striker Lukas Podolski scored twice in the opening half-hour as the Premier League leaders romped to a 4-0 win over third-tier Coventry City in their FA Cup fourth round tie at the Emirates on Friday.
Nicolas Anelka rescued Chelsea's FA Cup hopes on Saturday, scoring a hat-trick in a 3-1 victory at Watford to avoid a shock fifth-round exit. In their first game since Luiz Felipe Scolari was sacked and with replacement manager Guus Hiddink watching in the stands, Chelsea fell behind to the Championship (second division) strugglers when Tamas Priskin netted with 21 minutes remaining.
English third-tier club Sheffield United kept alive their FA Cup dream on Sunday when two goals in as many minutes gave them a 2-0 victory over Charlton Athletic and a place in the semi-finals.
Arsenal's defence of the trophy ended with something of a whimper as Mikel Arteta's side struggled with repeatedly sloppy defending.
West Ham United's record buy Dean Ashton scored twice in a 2-1 win at Manchester City
Liverpool have not beaten Manchester United in the FA Cup for 85 years
Manchester United reached the FA Cup fifth round and avoided any further embarrassment.
Holders Chelsea eased into the FA Cup quarter-finals with a 4-1 home victory over Championship (second division) side Cardiff City on Saturday while Portsmouth won by the same score at local rivals Southampton. After a season of shocks, the upsets dried up in the fifth round as Birmingham City came from behind to win 2-1 at Championship side Derby County with a last-minute goal by Liam Ridgewell while Manchester City and Stoke City drew 1-1.
Holders Chelsea and Premier League champions Manchester United were bundled out of the FA Cup quarter-finals. Chelsea lost 1-0 at Championship (second division) side Barnsley, while Portsmouth won 1-0 at Old Trafford.
Manchester City reached the FA Cup final for the first time since 1981 after a dramatic 1-0 win over arch rivals Manchester United, who finished with 10 men after midfielder Paul Scholes was sent off 18 minutes from time.
From Royal Challengers Bengaluru's historic first IPL title to star javelin thrower Neeraj Chopra finally breaking the iconic 90-meter mark to India women winning their first cricket World Cup, this was the year of long-awaited victories and record-breaking feats.
Jack Wilshere's late strike gave Arsenal a 1-0 FA Cup third-round replay win over Swansea City and Wayne Rooney's first goal in over a month earned Manchester United a 1-0 victory over West Ham United on Wednesday.
Middlesbrough were rewarded for beating Manchester City with a trip to FA Cup holders Arsenal while Chelsea's conquerors Bradford City host Sunderland or Fulham after the fifth round draw on Monday.
Portsmouth beat Cardiff City 1-0 to win their first FA Cup since 1939.
Fourth-tier Newport County stunned former FA Cup winners Leeds United with a last-gasp 2-1 win in the third round to spark a joyous pitch invasion at their Rodney Parade ground on Sunday.
Favourites Chelsea will play Tottenham Hotspur in the FA Cup quarter-final tie at Stamford Bridge next month.
Leaders Manchester United will meet Premier League rivals Reading in the FA Cup fifth round.